Indigenous Method and Safety of Mitomycin C in Refractory Corrosive Esophageal Strictures

Caustic esophageal strictures still represent a challenge to endoscopist. Standard treatment is regular esophageal dilatation until the resolution of dysphagia. Caustic strictures require dilations more frequently for a positive clinical response [1]. Increasingly frequent dilation may become a selfdefeating cycle in refractory stricture as recurrent trauma to the mucosa, enhance scar formation through enhanced fibroblast proliferation and collagen deposition, and ultimately recurrence and potential worsening of the stricture [2,3]. In many cases endoscopic dilatation fails and therefore esophageal replacement is eventually required. Non operative management of refractory stricture is limited. No data available on safety and efficacy of Mitomycin c in refractory strictures.